When men have a very low sperm count, poor motility and poor morphology.

When men have vasectomy and sperm have been collected from the testicles or epididymis.

When men does not ejaculate any sperm but sperm have been collected from the testicles.

When men suffer with spinal cord injuries, diabetes and other disorders.

When fertilization does not occur in invitro fertilization (IVF) procedures.